Health and Safety Regulation in Hospitality Industry

Health and Safety Regulation in Hospitality Industry POLICY DEVELOPMENT IN THE HOSPITALITY INDUSTRY Question 1: In the context of the CDM Regulations and the refurbishment of a floor of bedrooms in a multi storey hotel, critically outline the purpose and content of the Health and Safety Plan and Health and Safety File. Discuss the relationship between the two components and how the Health and Safety File will be of benefit to contractors in the future. Critically assess the merits of the Building Regulations application process and construction technique utilised for Mcdonalds modular drive through restaurants. The following will evaluate the best way of refurbishing a floor of bedrooms in a multi storey hotel so that the renovated building complies with all relevant health and safety legislation and regulations. The requirement to meet all the relevant health and safety legislation and standards means that the designers and the builders of renovations are as legally responsible as the hotel owners for all breeches of those requirements. Failure to meet regulatory standards could leave the constructors liable for civil prosecution or prone to litigation by the hotel owners, the hotel staff besides the hotel guests. Prosecution or litigation that could take years after the original renovation was actually completed (Youell, 2003 p. 99). The best way to develop a renovation plan that will receive planning permission from the appropriate local authority is to know exactly which health and safety regulations the proposed renovation needs to fully comply with. If the hotel is exempt from any of the health and safety regulations or the hotel owners believe that it is exempt from those standards it is always best to double check. Besides ignorance of the law is not an excuse for breaking it, and it will not protect contractors from legal action been taken against them. Of more immediate concern for contractors tasked with renovations a failure to abide to all building or health and safety regulations could result in the refusal of planning permission. After all it will only cause delays if the renovation plans are refused planning permission or if such breeches of the health and safety standards are missed at that stage and leave the design firm as well as the hotel owners liable to prosecution or litigation. Renovation w ork that does not reach the required health and safety standards might not be good enough to last over the long-term without the need to be repaired or eventually replaced due to its low quality (Youell, 2003 p. 99). Therefore to ensure that the renovation proposals receive planning permission and are legally sound a Health and Safety Plan as well as a Health and Safety File are necessarily developed and maintained to safeguard the building contractors and the hotel owners from both accidents and legal proceedings. The purpose of the health and safety plan is to ensure that the hotel will be fully compliant with the health and safety regulations that it is required to meet so as to function legally as a hotel. To make a fully functioning health and safety plan not only needs a strong knowledge of relevant regulations; it also requires the blueprints or plans for the hotel itself. An understanding of the hotel’s layout is essential with regard to making the health and safety plan practical and well designed. The objective of the health and safety plan is to make sure all the safety measures within the hotel are clearly accessible thus allowing both hotel staff and all hotel guests to remain safe in any emergency situation. The content of the health and safety plan would include the design layout and the exact location of fire fighting equipment, first exits, fire alarms, and any available first aid facilities. The plan should also include where hotel employees and guests meet, should the hotel have to be evacuated, especially in the event of a fire taking hold of the premises. Consideration should also be given to the fitting of smoke alarms, fire alarms, and sprinkler systems (Youell, 2003 p. 99). Besides considering fire safety procedures, and first aid measures the health and safety plan should include measures to maintain hygiene standards in the kitchens, toilets, dining areas, and the guest bedrooms. Good hygiene standards are needed to ensure that the hotel remains clean, tidy, and free of dirt, allowing the hotel staff and all guests to avoid food poisoning or infection. The plan needs take into account the location of the kitchens, rubbish bins, and toilets in relation to the bedrooms used by guests. Poor hygiene standards and food poisoning could prove to be very bad for the future of the hotel, as it may bring it to the attention of environmental health officers that have the power to close it down until the hotel meets the minimum required regulatory standards (Bloomsbury, 2005 p.124). Another factor for maintaining the good hygiene of the hotel is the straightforward one of guests not wishing to return to dirty and unclean accommodation (Bloomsbury, 2005 p. 155). The purpose of the Health And Safety File is to record how the hotel complies with all relevant regulations before, during, and after the proposed renovations. The file is meant to ensure that the hotel sticks to the measures it set out in the Health and Safety Plan. The file should record the health and safety performance of the hotel with regard to the maintenance of equipment, facilities, as well as all the procedures that enhance safety standards or good hygiene. The Health and Safety File should also keep a note of all the training that the staff at the hotel is given in respect of maintaining and implementing safety measures and all hygiene standards. The hotel staff should ideally be given training to use fire fighting equipment when it is safe to do so, to provide first aid when needed, and carry out practice fire safety drills. When necessary staff will need to be given extra training should they not perform their duties to a high enough level to comply with the standards se t out in regulations. The Health and Safety File should also ensure that all hotel guests have access to information about the location of fire safety equipment, first aid facilities, and the assembly point in case of the hotel being evacuated (Youell, 2003 p. 99). There should be a strong relationship between the Health and Safety Plan and the Health and Safety File. The two items should compliment each other, as together they provide the means to plan and implement safety and hygiene standards at the hotel. The Health and Safety Plan sets out how the safety and hygiene standards will be achieved, whilst the Health and Safety File is intended to record what is actually happening at the hotel in terms of complying with regulations. The Health and Safety File by itself could be very useful to any contractors that need to carry out any building or renovation work at the hotel, as a means of checking the record of the hotel in meeting regulatory requirements. Contractors would be able to consult the Health and Safety File if they have any queries regarding the equipment, facilities, as well as the safety and hygiene procedures used by the staff at the hotel. If the Health and Safety File has been kept up to date consulting it will allow the contra ctors to know whether or not the hotel has been adhering to the regulations it is legally supposed to do at all times. Knowing if the hotel is not complying with regulation would give the contractor the opportunity to suggest building alterations or changes in safety and hygiene procedures that if implemented mean the hotel does comply with all relevant regulations (Bloomsbury, 2005 p. 155). There are ways of ensuring that a company only has to pay minimal attention to completing Health and Safety Plans and Files without breaking the regulations or ignoring the spirit of the law. The fast food company MacDonalds has probably devised the best way of minimising the planning permission required whilst adhering to the statutory safety and hygiene standards set out in regulations and legislation. As a company MacDonalds has made its fortune and its reputation by the mass standardisation of its restaurants, equipment, staff training, marketing image, and finally but by no means least its food products. People know what they are going to get when they go into a MacDonalds anywhere in the world, and more of them like it than dislike it (www.LHC.ORG.UK). MacDonalds believe that the standardisation process is definitely a successful strategy when it comes down to gaining rapid planning permission and complying with safety and hygiene standards. Planning authorities will be made aw are by the company that their restaurants are pr-designed to pass safety and hygiene standards, whilst all new staff will be fully trained to make sure that standards are always adhered to (Mason, 2005 p.44). The senior management are well aware of the benefits of standardisation, if one design passes safety and hygiene standards it is adopting that design for all its restaurants as that makes financial, marketing, and practical sense to do so (www.LHC.ORG.UK). MacDonalds have developed modular drive through restaurants as a method of constructing new outlets quickly at the same time as passing the Building Regulations application process. As a company MacDonalds has always set out to have all its ordinary and drive through restaurants designed to look exactly the same as each other as well as also having the same features and equipment. For MacDonalds having restaurants that look the same everywhere they are constructed has been a highly successful branding strategy and exercise that has allowed the firm to expand impressively across the globe. To be more precise it is a global franchise which, has expanded due to its high profits and relatively low capital costs (Mason, 2005 p. 44). However the merits of using modular designs go beyond marketing ploys and serve pragmatic purposes. When MacDonalds set out to design its modular drive through restaurants it certainly took the Building Regulation application process into account. The modular drive through restaurant was designed to meet safety and hygiene standards in as many countries as possible, so that they could be constructed in as many places as the company would like. The low cost of construction when combined with the ease of gaining planning at the same time as being able to pass all safety and hygiene standards makes buying into the MacDonalds franchise a good investment. The prefabricated structures have the advantage of not requiring a high degree of planning permission than buildings wholly constructed on site (www.LHC.ORG.UK). MacDonalds have found that with experience that prefabricated designs that already fully meet planning requirements and regulations will undoubtedly gain full building permission quickly wherever the proposed restaurant is located. The rapid gaining of building permission allows MacDonalds to have all its new drive through restaurants trading sooner rather than later. The new drive through restaurants thus quickly re-coup their modest construction costs and go into profit. Profits are not only made quickly; they are also made over a long-term basis as well. The use of prefabricated designs and materials therefore allows MacDonalds to expand its total number of restaurants at a much lower capital cost than many of its competitors. The beauty of the modular drive through restaurant design is that it is cheap and durable, yet it could also be quickly modified if it needed to be (Mason, 2005 p. 44). The modular design allows for standardised equipment to be fitted, equipment that could b e easily updated modified or completely replaced should building regulations alter, or if the company purchases improved equipment. The modular design is meant to be really simple to construct, maintain and keep clean. The simplicity of the kitchen areas is intended to make it easier to train staff to cook and prepare food as well as cleaning areas to maintain hygiene standards. The training of staff does not take long as all processes and procedures, as well as equipment and food is standardised. The simplicity of the whole operation means that food is prepared, cooked, and served faster (Bloomsbury, 2005 p. 117). Simplicity and standardisation keep costs low, product prices highly competitive, and the company’s profits high. Providing that all staff are trained and keep to the procedures they are taught the company should always be able to maintain safety and hygiene standards whilst never having to wait long for planning permission (www.LHC.ORG.UK). Question 2: Explain how the analysis of a local authority Development Plan can help the senior management team of a national hotel chain identify a suitable site for a new budget hotel in a particular locality? The majority of local authorities in Britain will have development plans to control where and whether new businesses or retail units would be constructed within the areas they control the planning for. Local authorities make up Development Plans as a means of generating wealth, creating jobs and regenerating run down districts and would wish to include such firms within their Development Plan. Development Plan would include the precise locations of where the new offices, hotels, and retail units would be sited. The Development Plan provides further useful information for the senior management to consider besides the proposed or the approved locations of other companies. For instance, every Development Plan should give the location of roads, motorways, railways, and rivers near or within the locality controlled by the local authority concerned. Other information that could be relevant to the locating of the new budget hotel could include local tourist attractions or places that would make hotels less attractive for potential guests, like waste ground, factories, or prisons. If the new budget hotel could be located near the most attractive features of the town or city it is a bonus in terms of marketing the hotel before it opens and expanding the number guests once it has opened. If the company has to locate the hotel in a less attractive site the company could consider pulling out of its construction or consider different ways of marketing it if it is actually built. The company would however wish to avoid being located in areas where it could not guarantee the safety of their guests and their staff, as more would have to be spent on security measures such as fencing or patrolled car parks. The company could find it useful to contact local people and possibly the Police to find out which parts of the town or city they need to avoid when picking the locality of their new budget hotel. Local authorities will make the Development Plan available for the public and b usinesses to examine which allows any firms that wish to open premises within the area to apply for a place within that plan. For the Senior Management of a budget hotel chain that would want to open a new hotel inside a particular locality being able to analyse the local authority’s Development Plan would offer definite advantages when it comes to making the new budget hotel a long-term success (www.LHC.ORG.UK). The exact location of any new budget hotel could make all the difference between it being a successful part of the firm or it being a loss making failure. From a study of the Development Plan the Senior Management should be aware of the alternative sites available for the location of the proposed new hotel, as well as the placing of other new businesses within the development area. Senior Management should have a strong knowledge of the best places and the worst places to locate new budget hotels when it comes down to maximising the number of guests that stay there. Analysing the Development Plan would make Senior Management fully aware of the local authority intentions of which firms to allocate land to, for the construction of their new outlets, offices, or hotels. The most prestigious firms will want to locate in the most prime positions possible to fit in with their corporate image, whilst a low budget hotel firm might not need to do the same. A low budget hotel does not have to obtain a prestigious land site, it does however have to be based if at all possible on land that is near to town or city centres, and ideally is easily accessible for as many potential guests as possible. The senior management would find it useful to locate the new budget hotel near the main roads, the railway, close to local businesses, and preferably with free secure car parking spaces available. Such a location would be a good selling point to business travellers and tourists a like. If they could gain an accurate analysis of the Development Plan then it increases the chances of securing a good locality for the new budget hotel (www.LHC.ORG.UK). The hotel company could benefit from examining the Development Plan as it would allow them to know if they could use prefabricated designs that permit the construction to be finished earlier and thus earning revenue sooner. If the hotel chain already uses prefabricated designs and construction techniques then it will them greater flexibility when it comes down to the precise locality of the new budget hotel. Flexibility that stems from the savings in construction costs being able to provide a bit of leeway if the price of being in a better location is higher than first anticipated. A sound understanding of the development plan would enable senior management to have the locality and the rapid construction of the new budget hotel finalised as soon as possible. Such an understanding would thus grant the company more time to advertise the opening of the new hotel at an early stage to maximise the number of guests upon its opening. The evaluation of the Development Plan would also give se nior management a precise idea of the number of hotels within the town or city that are already built and those hotels that are planned. Knowledge of the hotels within the district gives senior management invaluable information when it comes down to the marketing, and pricing strategy for the new budget hotel which could make all the difference between success and failure. Knowing the nature, location, as well as the strengths and the weaknesses of all its rivals within the locality could certainly prove very beneficial to the senior management in selling the merits of the new budget hotel in relation to its competitors. Senior management could also take advantage of the company’s brand name and its reputation. Marketing for the new budget hotel should emphasis that the locality will soon be able to benefit from the arrival of a low cost hotel that happens to provide high quality service (www.LHC.ORG.UK). Bibliography Bloomsbury Reference, (2005) Dictionary of Leisure, Travel, and Tourism – 3rd edition, Bloomsbury, London Mason P (2005) Tourism Impacts, Planning and Management, Elsvier, London www.LHC.ORG.UK Youell R, (2003) Complete A-Z Travel Leisure Handbook – 2nd edition, Hodder Stoughton, London

America and Multilateralism: A History

America and Multilateralism: A History Perhaps it is safe to surmise from the very beginning that there does not appear to be a country in the world that is not affected or has not been affected in one way or the other by the United States of America. Short of this, there most certainly does not remain in existence a country, people or society which has no knowledge, however limited, of the United States of America. No single day passes without the American power being addressed or diagnosed in one capacity or the other by the global media. Over time, but in particular, in more recent times, no other country’s political, domestic, economic defence or capabilities and abilities have been more studied or discussed than the extent at which America has been. In actual fact, it is safe to surmise that very few political issues today provoke such strong and diverse responses as the role of the United States of America in its attempt to re-shape world affairs.[1] The recent terrorist attack on America of grave consequence s, its reaction to it and the wars in Afghanistan as well as Iraq have intensified the debate about the nature and prospects of American super power. There remains a school of thought that continues to celebrate the United States’ achievements in proclaiming as well as bringing liberty, democracy and prosperity to every corner of the world. Others are more inclined towards condemnation of America’s pursuit of hegemonic status and its attempt to impose a single economic system and a narrow set of moral belief on other nations around the world. Whichever school of thought one belongs to re America’s performance on the international podium, most have arrived at the conclusion that the history of the twenty-first century will be determined to a large extent by the way American power is used, and by the way in which other major political players on the international front react to it. The nation has often been referred to as an imperial, an empire or hegemony. Most p eople still continue to perceive America as that democratic land of roses where ‘anything can happen’. Some still believe in, especially those outside the shores of the country and straining to one day be admitted into the great country, what they call the ‘American Dream’. It is supposedly a country where ‘anything is possible’. Often times however, America is no longer beheld with rose tinted spectacles. Given its recent history world over, this is hardly a surprise of any significance. The word which best comes to mind when America, that great nation is under discussion as it constantly is for diverse reasons, is hegemony. What, it might be useful to enquire at this juncture, is hegemony? In lay man’s terms, hegemony, succinctly put, is leadership by predominance (some might even say aggression) of smaller and weaker states or nations by naturally bigger nations in an effort to achieve world domination. Does America therefore stand ri ghtly accused of attempting to dominate the world through its conceptualisation of global politics, foreign policies and armed forces, or at least to dominate those nations which are considered smaller and weaker? It is common knowledge that while some countries practice communism or socialism, America was and remains a capitalist country where the motto right after ‘In God We Trust’ is a universally accepted but unspoken ‘survival of the fittest’. In the introductory words of G. John Ikenberry in his book ‘America Unrivalled’, â€Å"The pr-eminence of American power today is unprecedented in modern history. No other great power has enjoyed such formidable advantages in military, economic, technological, cultural or political capabilities. We live in a one-super power world, and there is no serious competition in sight†[2] These words immediately bring to mind perhaps the most controversial wars of all times and America’s gargantuan contribution or one might even dare say blatant single minded orchestration of the same, the Iraqi invasion (and on-going war till date) in 2003. It is worth reminiscing at this juncture how the world watched and waited with bated breath while the United Nations deliberated on whether or not the United States should be granted the authorisation to invade Iraq based on its reports about the so-called axis of evil and the weapons of mass destruction they supposedly had in the making which it further claimed posed un-foretold threats to the international world. It is yet another point in favour of the argument that America is fast becoming or indeed has all but attained the status of an hegemonic state that President George W. Bush announced to the world that regardless of the UN’s decision and that of its Member States, America will forge ahead in war against Ir aq and Afghanistan, alone if they had to. In his exact words, â€Å"†¦when it comes to our security, we really do not need anyone’s permission†[3] It was later argued that it would appear that even the United Nations, a so-called world moderator and international emblem of peace, is nothing but yet another tool in America’s already brimming tool box. Although at the time, this announcement from the Bush Administration sounded as arrogant and ‘above the law’ as it really was, there were many who felt America would be justified in its decision in the wake of the September 11 attack. September 11 2001 (hereafter referred to as 9/11) brought about the turning point in history, international law and the use of force against terrorism. The words of an American man considered very patriotic indeed comes to mind at this controversial stance of George W. Bush re brushing off the world’s opinion and/approval to its use of force in the name of figh ting terrorism. The man, none other than Richard Holbrooke, former United States ambassador to the United Nations, who once stated after careful observation, one should imagine, that the Bush administration threatens to make a â€Å"radical break with 55 years of a bipartisan tradition that sought international agreements and regimes of benefit to us†[4] Many years, loss of lives both civilian and military, reports of horrible treatments meted out to prisoners of war (PWO) by the American soldiers against every rule of Humanitarian Law and the Geneva Convention, America’s refusal to withdraw its troops even after the fall of Saddam Hussein (its greatest enemy) the question on everyone’s lips is whether the war was indeed for all the altruistic reasons quoted by America in its rather fabricated reports or for more reasons closer to home. The question can even be posed all the way back to Operation Desert Storm in the same Iraq in 1993. Did America invade Iraq on both occasions for economic gain and ultimately to place itself as the world’s super power. Although it appears now to the world that the Bush administration is the one responsible for dramatically drawing America away from multilateralism, a look back into the Clinton administration will confirm that this is not remotely true. Under the Clinton administration, America neither waited for the United Nation’s approval/authorisation before deploying the North Atlantic Treaty Operation (NATO) to Serbia in 1999 nor prior to its bomb attack on Iraq in 1998. There were also other Conventions, Acts and Treaties America rather conspicuously refrained from signing or ratifying such as the banning of further use of Land Mines (the Ottawa Convention of 1997). The difference perhaps would be where the Clinton administration adopted diplomacy in its delivery of such unilateral decisions; the Bush administration simply forges ahead with no regard for the world’s opinion, appro val or in most cases disapproval. In the era immediately after the World War (II), America’s strength was not only viewed during the war with the deployment of its armed forces, which later formed an alliance with the United Kingdom amongst others (the allied forces) but also after the war in its attempt to rebuild Germany as well as other war torn countries in the war aftermath. In this, America had strategised and was apparently successful in ensuring that the world did not revert to its closed regional dealings of the 1930s prior to the war. The founding of the United Nations on 24 October 1945 also saw to it that the beginning of what is now known as globalisation was established. A post war era of multilateral character and significance was thus built around economic and security agreements such as the Bretton Woods Agreement on monetary as well as trade relations among nations. The American-led NATO security pact followed much later. This international order which came into existence after the war (World War II) was effectively one which was multilateral in character. A more open system of trade and investments began to emerge, largely encouraged by America. Economic and security matters as well as political relations became indistinguishable and indivisible among nations in what is best described as an open world market or globalisation. This is evident in the General Agreement on Tariffs and Trade (GATT) as well as the Bretton Woods agreement earlier mentioned. An alliance tie emerged between the United States and the Great Britain in particular and the European continent in general in a scenario one could simply put in lay man’s terms ‘rub my back and I will rub yours’. America’s economic as well as security assistance to the Asian region is also worth mentioning. America ensured and continues so to do, that weaker and smaller states are afforded security assistance, protection and granted access to its markets, technology and country in general. In th e wake of America’s Green Card Lottery scheme, the support and admiration of other smaller states for which the scheme was intended and who continues to benefit from the same was firmly secured. In a similar vein after the world war, citizens of many nations flocked in their thousands to America from world over and started life over again after the war. In what is not unlike the stone age ‘trade by barter’ arrangement, the participating states in turn continue to ensure that political stability is maintained in their relationship with the United States, making available to America their diplomatic, economic and logistical support in return. For instance, America has training grounds in Saudi Arabia and Kuwait, perhaps as a lasting result of Operation Desert Storm. Going back in history however, it remains indelible that there were 5 world super powers including America itself. How then can Ikenberry infer that America has no competition in sight in its steady climb to the top in the international hemisphere? Who were the other four super powers and what became of them? The five major contenders when the United Nations was founded in 1945 were Russia, Great Britain, China, and France. It is accurate to say that the cold war put paid to Russia’s contention with America. The Great Britain, as exhibited more recently under the Tony Blair administration is more or less a lap-dog to American’s policies and remains a rather very friendly ally than a potential contender. Yet it will be nothing short of fallacious argument to say that America has no contender or is without competition in one form or the other. Worth remembering as well is Germany and France’s initial reluctance as well as refusal to throw their weight behind the Ir aqi invasion in 2003. America’s hegemonic state is therefore not without challenges as well as challengers, it is however the multifaceted character of America’s power that makes the country so far reaching, daunting, provocative and formidable to less equipped and smaller countries. The collapse of the Soviet Union in the Cold War saw an acute decline in rival ideologies and even tighter alliances formed between the United States and other regions. Following the Cold War, America continued to grow from strength to strength. In the 1990s its economy was commendably and successfully restructured. Also growing in significant progression alongside its economy is its armed forces and global recognition as a state to reckon with. By the turn of the millennium, America’s economic and military growth had wedged a seemingly insurmountable gulf between itself and other major players in world politics. While the late 90s saw Japan’s economy grow by 9 per cent, the European Union altogether by 15 per cent, American economy grew by a significant 27 per cent, nearly doubling and tripling that of the other regions.[5] This did not go unnoticed by the rest of the world. In fact literally doffing his hat to the United States in a speech in Paris (1999), the French Foreign Minister, Hubert Vedrine, observed that the growth witnessed by the world in America â€Å"is not comparable in terms of power and influence to anything known in modern history†[6] America’s devotion to its armed forces can by no means be ignored. America boasts an army that is better equipped and out numbers the armed troops of well over 14 countries put together. There are training grounds for the United States army in well over 40 locations world wide. This automatically means that when another weaker or slightly less advantageous state envisages itself in trouble, the first point of call for protection and assistance, when and if necessary is the United States of America. In its usual confidential, bordering on arrogant manner America’s National Security Strategy declared to the world that their forces will be strong enough to dissuade potential adversaries/would-be challengers from pursuing a military build-up in hopes of surpassing, or even remotely equalling, the power of the United States.[7] It is not impossible or even unthinkable for America to utilise its military capacity to impose its policies on other states in different regions of the world. It has been observed already that America spends on its armed forces more than the next fourteen countries combined and that the U.S. military expenditures will shortly be equal to the rest of the world combined.[8] Another scholar of repute, Paul Kennedy, also surmised that it is already the case that all the other navies in the world combined could not dent American maritime supremacy.[9] Still on the issue of security, expressing his own opinion and an opinion apparently shared by many others world over, Barry Possen has suggested that the United States’ command of the sea, space, and air forces is the ‘key military enabler of the U.S. global power position’.[10] Assuming its economic growth remains as healthy as it has been since the 90s, the concentration of world military power may continue for several decades yet. Even at the current level of U.S. capabilities, it is the general view that ‘the United States can shoulder the burden of maint aining global security without much help from Europe’ or the rest of the world for that matter.[11] It begins to appear obvious that perhaps America’s initial support for multilateralism in international trade and globalisation was borne of a grander strategic move to acquire and retain more power while legitimately promoting international reliance of one state on the other, one region on others for support, growth and assistance. A quick glimpse at major historical turning points such as 1919, the end of World War II in 1945 and the period immediately after the Cold War all but confirms this logic. It would appear that America promoted multilateralism in such a strategic way so as to signal restraint and commitment from other states.[12] This precipitated the acquisition of support, if not actual trust, acquiescence and cooperation of other weaker states. But surely when one country is placed so much higher than others in the case of all animals are equal but some more than others, there naturally arises the problem of balance of power or even equality before the law. What the majority of member states may attempt with the United Nations and come out facing adverse repercussions for is the same thing the United States will not only attempt but carry out and come out smelling of roses. For the sake of this discussion, should one be given to a flight of fancy however fleetingly and imagine or a moment that a member state such as Ghana or Nigeria threatens the use of force against Cameroon and declares to the world that the same will be effected whether or not the United Nations and indeed the world approves of its actions. At the very least, economic sanctions will immediately be placed on such a country. However in the name and under the umbrella of 9/11 it would appear that America is permitted to do and undo whatever catches its fancy and of course promotes its economic as well as military growth. How else can one begin to explain the issue of thousands held prisoner at the US military operated prison and indeed a recreation of Camp Delta, Guantanamo Bay, for years with neither charges nor trial in the name of fighting terrorism? America claims not to have jurisdiction in Cuba to try these prisoners yet it has the power and the authority to imprison them in Guantanamo Bay. What, one is right to ask, happened to the universal (at least in democratic states) ‘writ of habeas corpus’? Another example of America’s marked shift from multilateralism to unilateralism and establishing itself as a super power above the rest of the world is again glimpsed shortly after the controversial invasion of Iraq in 2003, when America was quick to submit allegations against North Korea as well as Iran for also becoming threats to the international community as they were manufacturing nuclear weapons. In an ironical twist however, in 1998, Japan, perhaps once one of America’s closest allies, was reportedly furious with America when its officials unilaterally decided that funding for North Korean Nuclear reactors was to con tinue despite Japan’s complaints that North Korea was firing missile over its territory.[13] What then can possibly put an end to America’s domination of the international stage and its rise towards a super power of hegemonic characteristics? It has been established that the two most important factors in the growth of any nation; its economy and defence, remain the two areas where America continues to excel and prosper rendering it even more of a force to reckon with by other nations of the world. Is it then any wonder that many are of the school of thought that it is only a matter of time before America seeks to completely dominate the world and by so doing, simply crush out weaker states of the world. It is enough to alert the world that more than any other administration before it, the Bush administration is significantly departing from materialism especially on agreements dealing with arms control and proliferation. Multilateralism, as Ikenberry’s book posed the debate, does indeed seem to be on the decline in America’s policy and political stance. I t has become to America a selective game where multilateralism is embraced when it adds to the muscles in its already bulky biceps and unilateralism at every other turn. As America continues to systematically depart from multilateralism and promote more unilateralism in its foreign policies and decisions on security affairs affecting not only its boundaries (assuming such a word as ‘boundary’ exists in the American dictionary) but also spread ashore to other nations of the world, the world may very well be moving rather rapidly towards the final unravelling of America as a hegemonic nation. What and who in the world can then possibly challenge America’s hegemony? Surely it would take a large scale war or a crucial global economic crisis to challenge or even come close to threatening America’s hegemony. While this might be very well put and even precise in theory, surely either option will definitely have grave repercussions on the international community. However, Ikenberry argues in his book, ‘America Unrivalled’, that there are limits to the United States’ hegemony such as it stands at the moment. He is of the opinion that a complete hegemonic order would require not just preponderant capabilities but also some significant degree of acquiescence on the part of other states, especially the other major players in world politics for the maintenance of such order. Following the Cold war, America acquired the support and cooperation of one of the major players in that region, Japan. Japan was once America’s closest ally as a result of this, however even Japan is becoming resentful, as presumably are the rest of the world, at America’s increased unilateralism (as in the North Korean case mentioned above) and the selective choice of multilateralism only when it favours the nation in one form of economic or security purpose or the other. It is therefore not impossible that other major players in the world, on examining their alternatives on how to best rid America of its hegemonic status and by so doing release the unsuspecting world from American domination, may very well challenge its hegemonic position. Capitalising on the regional and international relationships once promoted by America, the other major super powers in the Asian Region and the European Union could orchestrate an over throw of America’s position as an hegemonic state or at the very least challenge the same. Not ignoring the power and importance of smaller or weaker states however, they would quite naturally also have to be involved. This however would be an all scale war, the magnitude, repercussion and significance of which will tremble the world perhaps more than every previous wars put together! Any would-be hegemonic challenger would most naturally have already arrived at the very same conclusion. Apart from the fact that every single one of these would-be challengers rely on the United States for one as pect of its sustenance or the other, it would take a lot of consideration, meetings, strategising and concrete persuasion to convince every member state of the necessity of such a global war. With its present and ever growing resources both at home and abroad, it is therefore only a matter of time before America, at whom the war is intended, becomes aware of the plans and builds up enough or adequate defence against the same. While it is not impossible that several nations of the world may come together and challenge America’s build up to hegemony, to say that the world may never recover from such a large scale war may perhaps be the understatement of the existence of mankind. In a brief state of fantasy, were one to assume that this large scale war does take place and does remove America from the pinnacle of power it currently occupies, there is no telling how many decades or even centuries it would take to rebuild a world of international trade and globalisation. Another da nger in that is another country seizing the opportunity and rising very rapidly to the throne of hegemony, in this instance however, a country not so democratically inclined as America, for instance, China. The world as we know it now may cease to exist as a result of such a war. It is now 2008 yet traces of the Second World War still remain evident in some areas in the Eastern part of Germany as one imagines it does in other affected parts of the world. If the argument here is then that a full blown war against America’s hegemony may do the world greater harm than good, what then can possibly stop America’s climb to the top of the world? As mentioned earlier, the strength of any nation lies in its economic as well as military growth. One, quite naturally, is not devoid of the other however as training camps, gears and facilities will be difficult to procure without a booming economy. Should the world then experience a global economic crisis, the like of which it is yet to ever experience, perhaps this will in a way also bring America to the same level as other countries or at least less dominant? In this present day, at least the European Union and America are experiencing an economic crisis that has been likened to the worst in many decades till date. The Great Britain’s Royal Bank of Scotland recently announced that the country is indeed in recession. China and Japan have also reported major decline in sales and poor performances on their Wall Street equivalent. Japan has actually announced to the world, like Great Britain, that it is indeed in the middle of a torrid recession. While this economic crisis may very well be unpleasant and indeed wrecking a lot of harm on the economy of the countries involved, it will take much more than this to cripple America or to reduce its hegemonic status. Even at this point in time, the US Dollar continues to rise against the British Pound and the Euro. Should the world experience an economic crisis of such negative significance that all the major states as well as even the ones considered smaller and weaker are effectively affected, America’s hegemony, in my humble opinion, will most certainly be thoroughly challenged. This will be brought about by the fact that the international community in a bid to survive and revert to some semblance of normality will be forced to depend one on the other for that means to survival, America included. Such a scenario will almost take the world back in history to the early days when the advantages of globalisation and inter dependence of nations on one another was first discovered. Such an economic crisis w ill render it almost impossible for states to continue to concentrate on military training and equipments. One should imagine that nations will be more concerned with the immediate welfare of their people such as housing, medical care and social services as undoubtedly unemployment will rise astronomically in the face of an economic crisis of any significant magnitude. From everything hereinabove appearing and the examination of different (learned) opinions as well as scenarios, it is therefore perhaps appropriate to conclude by agreeing with the debate that should a full blown war orchestrated by would-be challengers of America’s hegemonic state fail, surely an economic crisis of significant global scale will not only challenge but also probably, however temporarily, bring an end to America’s hegemony. America will be forced to revert to the multilateralism way of international politics and to abandon unilateralism in a bid to promote globalisation and a closer knit international community. Bibliography John, G. Ikenberry, ‘America Unrivalled: The Future of the Balance of Power’ (Cornell University Press, 2002) John, Ikenberry, ‘Is American Multilateralism in Decline?’ Perspectives on Politics 1:3 (2003) ‘Hegemony or Empire’ The Redefinition of US Power under George W. Bush, Edited by Charles-Philippe David and David Grondin (2006) Richard Little, Michael Smith, ‘Perspectives on World Politics’ Ikenberry, G. John, ‘Liberalism and Empire: Logics of Order In The American Unipolar Age’, Review of International Studies (2004) Stephen M. Walt, ‘Keeping the World â€Å"Off-Balance†: Self-Restraint and U.S. Foreign Policy’, in Ikenberry, America Unrivalled, pp. 121-154. Charles A. Kupchan, ‘Hollow Hegemony or Stable Multipolarity?’, in G. John Ikenberry (ed.), America Unrivalled: The Future of the Balance of Power (Ithaca, NY: Cornell University Press, 2002), p. 72. According to Kupchan, the European Union is emerging as the main competitor of the United States in a future multipolar international system. Whither American Power? David Held and Mathias Koenig-Archibugi Published in: American Power in the Twentieth-First Century, edited by David Held and Mathias Koenig-Archibugi, Cambridge: Polity Press, 2004. Kennedy, Paul, ‘The Rise and Fall of the Great Powers’ 1987 Footnotes [1] David Held and Mathias Koenig-Archibugi, ‘Whither American Power?’ In American Power in the Twentieth-First Century [2] G. John, Ikenberry ‘America Unrivalled’ Pp 1 [3] Quoted in Balz 2003, A1 [4] Purdum 2002., 1 [5] Ikenberry [6] Quoted in Craig R. Whitney, ‘NATO at 50’ With Nations at Odds, Is It A Misalliance? New York Times 2, 1999 [7] President of the United States, The National Security Strategy of the United States of America (Washington D.C.: White House, September 2002), p. 30. [8] G. John Ikenberry [9] Paul Kennedy, ‘The Greatest Superpower Ever’, New Perspectives Quarterly, 19 (2002). [10] Barry R. Posen, ‘Command of the Commons: The Military Foundation of U.S. Hegemony’, International Security, 28 (2003), pp. 5-46, p. 8. [11] On the durability of U.S. supremacy see William C. Wohlforth, ‘The Stability of a Unipolar World’, International Security, 24 (1999), pp. 5–41. [12] Argument was developed by Ikenberry 2001 [13] Marshall and Mann, ‘Goodwill Towards the United States is Dwindling Globally’

Slavery and the Caribbean :: Slavery Essays

Slavery and the Caribbean Europeans came into contact with the Caribbean after Columbus's momentous journeys in 1492, 1496 and 1498. The desire for expansion and trade led to the settlement of the colonies. The indigenous peoples, according to our sources mostly peaceful Tainos and warlike Caribs, proved to be unsuitable for slave labour in the newly formed plantations, and they were quickly and brutally decimated. The descendants of this once thriving community can now only be found in Guiana and Trinidad. The slave trade which had already begun on the West Coast of Africa provided the needed labour, and a period from 1496 (Columbus's second voyage) to 1838 saw Africans flogged and tortured in an effort to assimilate them into the plantation economy. Slave labour supplied the most coveted and important items in Atlantic and European commerce: the sugar, coffee, cotton and cacao of the Caribbean; the tobacco, rice and indigo of North America; the gold and sugar of Portuguese and Spanish South America. These commodities comprised about a third of the value of European commerce, a figure inflated by regulations that obliged colonial products to be brought to the metropolis prior to their re-export to other destinations. Atlantic navigation and European settlement of the New World made the Americas Europe's most convenient and practical source of tropical and sub-tropical produce. The rate of growth of Atlantic trade in the eighteenth century had outstripped all other branches of European commerce and created fabulous fortunes. An estimate of the slave population in the British Caribbean in Robin Blackburn's study, The Overthrow of Colonial Slavery: 1776-1848, puts the slave numbers at 428,000 out of a population of 500,000, so the number of slaves vastly exceeded the number of white owners and overseers. Absentee plantation owners added to the unrest. Rebellion was common, with the forms including self mutilation, suicide and infanticide as well as escape and maroonage (whereby the slaves escaped into the hills and wooded interiors of the islands and set up potentially threatening communities of their own. See references in Wide Sargasso Sea). Jamaica holds the record for slave revolts, with serious uprisings in 1655, 1673, 1760 and continued disquiet after that. The documentation of revolts in Trinidad is less complete, but we know of at least one serious plot in 1805. Guiana was actually governed by a slave named Cuffy for a year after the revolt in 1763, and Barbados also had numerous plots, including s ix between 1649 and 1701.

Another Albert Einstein :: essays research papers

Albert Einstein was a great man who contributed many theories and ideas to the world of science. Some people considered him one of the smartest human beings alive. The theory of relativity is also said to be â€Å"held as the human thought of highest quality. Albert Einstein was born in Ulm, Germany in 1879. In 1894, Einstein’s family moved to Milan. Einstein went to Switzerland, and he attended Aarau Secondary School. There, he received his Swiss Citizenship. Afterwards, Einstein returned back to his home, Ulm Germany, and studied to become a mathematics and physics teacher. Later in 1902-1909, he worked at the patent office, as an examiner in Bern. He obtained his doctorate while working there. During this time he developed the theory of relativity, in 1905, which explained the photoelectric effect and studied the motion of atoms. The theory, E=mc explained that mass and energy were equivalent. Later in 1908, he became a lecturer at the University of Bern. Then eventually in 1909, he became a physics teacher back at the University of Bern. As you can see, Einstein had a very busy academic life. By this time, Einstein’s incredible knowledge had attracted many scientists. In 1910, he became a professor at the German University, in Prague. By 1913, Einstein had become famous internationally. In 1921, Einstein was awarded with the Nobel Prize for his incredible work in physics, especially his theory of Relativity. In 1933, he accepted a place at Princeton, the institute for advanced study. Einstein became very happy in 1940, when he became an American citizen. Although, Einstein was very worried about the possible use of Atomic Energy in bombs. He wrote to the President of the United States, Franklin Roosevelt, to investigate this. Einstein wanted world peace and disagreed with wars. Here is a more detailed explanation of Einstein’s Theory of Relativity. Einstein's early work on the theory of relativity (1905) dealt only with systems or observers in uniform (unaccelerated) motion with respect to one another and is referred to as the special theory of relativity; among other results, it demonstrated that two observers moving at great speed with respect to each other will disagree about measurements of length and time intervals made in each other's systems, that the speed of light is the limiting speed of all bodies having mass, and that mass and energy are equivalent. Overall Einstein had wished that his theories would be very simple and easy to understand, but no matter how simple he made them, they were still hard to interpret.

The Rivalry Between Boeing and Airbus Essay -- Economics Airlines Airc

The Rivalry Between Boeing and Airbus The rivalry between Boeing and Airbus goes back a long way, when Boeing was by far the dominant supplier of commercial airplanes. Up until 1997, Boeing was the clear market leader on the passenger airplane market. Now the situation is less certain, as Airbus has overtaken its American competitor[1] not only in the domestic market but also in the world market, with its introduction of new models of passenger aircrafts. The main issue addressed in this article is that a 1992 U.S.-EU civilian aircraft pact allows too much European government support for Airbus, helping it sell more jetliners than Boeing, which had an 80% share in the market a decade ago. Thus the U.S. government wants the E.U. to put an end to any new subsidies provided by their government, which are aimed at protecting their aerospace industry. The market structure for the aerospace sector is oligopolistic i.e. there are few enough firms to enable barriers to entry to new firms because of various reasons such as huge capital investments and high technology. Hence, Boeing and Airbus, which are the two giants in the aerospace industry, have virtually split the market. When Airbus was first set up, it faced a lot of competition from Boeing. This civilian aircraft pact allowed the European government to take protectionist measures by providing various government subsidies to its developing high –technology industry (i.e. Airbus) so that it could compete with Boeing in the international market. The diagram below illustrates the impact of the subsidies on the quantity supplied by Airbus in the domestic market. In the diagram we assume that the world supply is perfectly elastic at Pw. Under conditions o... ... disputes and worsen trade realtionships between the U.S. and the E.U. The E.U. government was justified in providing subsidies to Airbus earlier. This is because Boeing were the clear market leaders and had established a monopoly power (i.e. Boeing was the only major industry in the aerospace sector) not only in the world market, but also in the local European market. Hence, this posed as a big threat to Airbus, since they were not able to compete in the world and local market and this could have lead to the decline of the aerospace industry of Airbus. But now, since Airbus has established itself as one of the main producers in the aerospace sector, future subsidies are not desirable for free trade. References: Essential of Economics – John Sloman http://news.bbc.co.uk/1/hi/business/125726.stm [1] http://news.bbc.co.uk/1/hi/business/125726.stm

Cell and Molecular Biology

Cell and Molecular Biology Final Name: Hadeel Binomar30 pts. Protein misfolding can be an aspect of several different human disorders, including cystic fibrosis, Alzheimer's disease, and atherosclerosis. Many times, the misfolded protein is a membrane protein. In fact, a type of diabetes insipidus results from a mutation in the G-protein-coupled vasopressin 2 receptor that prevents the protein from making it to the cell membrane A) Describe how this type of receptor would normally get targeted to the membrane (from the beginning of translation) and B) then propose one mechanism by which the mutation could cause a lack of proper targeting. One of the most important protein's target is G protein-coupled receptors, several signaling mechanisms depend on this type of receptor to change both internal and external stimuli to the intracellular responses. Basically, one of the G couple receptor subfamilies is G-coupled Vasopressin-2- Receptor (V2R), and this receptor is going through a strict quality control process at the endoplasmic reticulum, which presents the only correctly folded protein to gets through the secretory pathway. The primary function of the V2 receptor is to activate the attached G protein that bound to the ? subunit then phosphorylated to GTP. The G protein couple receptor then activates the enzyme adenylate cyclase that catalyzes the reaction in the ER and forms cAMP from ATP. After that, cAMP acts as a second messenger and activates a protein kinase that phosphorylates the integral membrane proteins on the cell surface. Moreover, the secretory pathway organelles' and the plasma membrane both are first introduced into the Endoplasmic reticulum, and the co-translationally proteins that can cross the ER are synthesized by the ribosome first then binds by chaperones to gets moves to the ER surface using GTP that allows them to move toward the receptor then release it. The soluble proteins and the integral membrane proteins as I mentioned above, can be targeted through the ER and then translocated by the same mechanism.Further, several mutations occurring in the transmembrane region which affect the structure of the protein. These are multiple mutation sites, such as mutations occurring in the amino acid residues which was acting as a causative agent for human disease. Also, there are other mutations occurring on the single site position that will affect the translation mechanism and cause many human diseases like: cystic fibrosis, Alzheimer's disease, and atherosclerosis that proves the function of V2R protein which plays important role in the translation during the protein folding process. One of the mechanism that may a reason for lacking the proper target protein is when the mutations of the CFTR gene occurring and affect the function of the chloride ion channels and cause defect in the protein sequences which lead to the production of diseases and misfolded of the proteins that are unable to recognize their functional destinations. Otherwise, Lack of the stop signals is another issue that prevents the protein from getting into the surface of the ER, also called the non-stop decay cellular pathway, because lack of this stop signals prevents mRNA from synthesis and translate the proteins, these consider as a point mutation that inhibits the essential stop codons. 30 pts. Describe the experiment shown in figure 3 from the paper we discussed in class (Miller et al, 2003). (A) In your description, consider the following questions: Why did they do it? How did they do it? What did they learn? (B) Diagram the results that you would expect to see in Lanes T, 1, 2, 3, and 4, if the amino acid signal DID in the protein Gap1p was mutated to random amino acids and tell why; and (C) Give two possible (different) results that might occur if the amino acid signal LxxLE in Bet1p was mutated to the amino acids DID (which are the signal in Gap1p). Diagram the results expected in Lanes T, 1, 2, 3, and 4 and explain why you predicted this result for each case.left20840701.A001.A4467225201739500The experiment was performed to study the role of cargo binding domain of Sec24p in the process of protein sorting. To perform this study, both mutant and wild types subunit Sec23/24p and Sec23/24L616W were harvested from microsomal membranes. The immunoblotting assay performed to quantify cargo molecules using radio-labeled secondary antibodies. Comparison of the mutant subunit with wild type illustrated omission of some molecules in mutant one, these molecules were cargo protein molecules. While some of them are packed in a way that similar to the wild-type. It meant that there were some signals that remained unaffected although mutation was there. Unexpectedly, it was found that in these unaffected molecules of mutation in Sec23/24p, packaging was better than the wild type. Further, they found the proteins that were highly affected had Bet1p and Gap1p/Sys1p chimera, because they completely depending on the Sys1p di-acidic of COPII vesicles. If the amino acid signal DID in the protein Gap1p was mutated to random amino acids, the resulting bands would be seen as in figure 1. A because the amino acids might be present in all the lanes. And Gap1p is required for di-acidic motifs to fuse together with the COPII vesicles at the mutated domain. Also, Sys1 peptide is not involved in Sec 23/24p hence its mutation is not contained in a di-acidic motif. If the signal LxxLE was mutated to the DID, the expected Bet1p packaging would be shown in figure 2. A as not be seen in lanes containing Bet1p because the amino acid signal LxxLE does not exit after mutating to amino acids DID. The second probability for the Bet1p would be expected to bind with the vesicle for packaging when it interacts with di-acidic motifs which is needed as shown in figure 2.B290512515621000581025113030004781550412752.B002.B6286501346202.A002.A20 pts. Explain the experiment shown in Figure 5C from the Shen et al. (2018) paper on the phosphorylation of CDC25 that we discussed in class. In addition, be sure to also address the following: A) why did they do this experiment (the central issue); B) what did they learn; and C) what is another control experiment they could have done? D) Would these results change if you added a constitutively active form of LKB1 to the reaction? If so, how and why? A) Overall, the main purpose of this paper is to explain how the division of cells is highly regulated such that cells that fail to pass some specific stage-based tests cannot advance to the proceeding stages. In this particular experiment, HeLa cells were subjected to chemicals that are known to activate the enzyme AMPK. Also, the main catabolic processes that are involved to generate energy for cells to transition from G1/G2 were determined by the application of radiochemical approaches, the experiment required to approve how highly conserved cellular energy sensor can significantly delay mitosis entry and activation of AMP-activated protein kinase (AMPK). Further, Wee 1 family inactivates the cell cycle G2/M Phase which is controlled by Cdc3/cyclic B (mitotic cyclin-dependent kinase complex). They found that AMPK-dependents phosphorylation of CDC25C arranges a metabolic control point for the M-phase transition and the cell cycle phase G2. B) Also, they learned that suppression of Wee 1 or acute induction partially reinstates mitosis ingress in the circumstance of activated protein kinase (AMPK). This experiment showed that when Phosphorylates Cdc25 is in a distributive and disordered state, it results into ultra-sensitivity in protein phosphorylation. C) For another control experiment, they might try exposing the U2OS (cell line) clones conditionally exhibiting Cdc25A etoposide. That will help to test whether Cdc25A degradation is significant for the G2 control point or not.D) If they add an active form of LKB1 to the reaction, the results will not change, because in cells LKBI activity inhibits AMPK activation in response to different stimulations. Also, LKBI is lost upon consistent isolation and therefore no effects of phosphates observed.20 pts. Briefly describe the role of cyclin-CDK in the cell cycle and give an example of positive and negative control in this system. Also, describe how cell cycle regulation links to the stimulation of apoptosis at the molecular level. In the beginning, the cell cycle depends on many basic factors that control the regulation process starting from the signal transcription molecules, growth factors and the Cyclin Dependent Kinases enzymes include the checkpoints which control the transition process between the cell cycle phases by binding to the cyclin proteins CDKs then phosphorylate other proteins to transfer from one phase to another. The role of transcription factors is to turn on the signals for gene expression, DNA replication, and cell divisions. As an example of CDKs, cyclin-dependent kinase 1 CDK1 is a cell division cycle protein homolog 2, that has a primary role in human cancer cells because CDK1 rather than any types of CDKs is fatal to the mutated version of MYC- dependent cancer that leads to a depletion of oncogenes like (Fos and Jun) in human cancer cells. Fos and Jun are combined forms of the transcription factor called AP1 that activates the delayed response genes such as cyclin D and CDK4. Recent studies reveal that the reason for the MYC breast cancer cells duplation is targeting CDF1 exhibit any other CDKs cell lines. Also, CDK1 inhibition can control and target the cancer cells in human and both phosphorylation and expression of MYC during the cell cycle process. To initiate intracellular signaling pathways and stimulate the cell cycle entry, mitogens substance bind to the cell surface receptor with the activation form of GTPase Ras that activates MAP kinase cascade. That will lead to the expression of encoding gene of the transcription regulatory protein like MYC. Moreover, E2F transcription factor is a target for cyclin D and CDKs that stimulate proteins expression to initiate S phase, also E2F regulated by the tumor suppressor gene Rb (Retinoblastoma protein). At early G1 Phase, Rb protein combined with E2f to form the histone deacetylases protein that remains chromatic condensed, then cyclin kinase phosphorylates Rb protein, causing it to disassociate from E2F. That allows recruitment of histone acetylates, which decondense the chromatin and helps transcription complexes to form in G1 and S phase and to form a positive feedback. For the negative control, if there are no growth factors present to stimulate the synthesis of Cyclin D in the new cell, Rb phosphorylated will turn off, and Rb will rebind to E2F, then the cell cycle will stop and that will lead to many negative results like prevent it to bind with DNA, or DNA damage and cells will return to the G0 phase. Apoptosis is a consequence of DNA damage; if the damage is not repaired, the cell cycle will divert towards apoptosis, otherwise, if the cell has DNA defects and fail to undergo apoptosis, that will change to the cancer cell. G1 phase regulators such as P53 and E2F are essential to promote the cell regulations and eliminate any damage or abnormal changes during the cell cycle. P53 has a primary function to prevent any mutation in DNA during cell progression, so any defect in P53 will lead to cancer, and it's usually mutated in cancer cells. Further, Rb protein considers as a tumor suppressor and also promotes apoptosis. Additionally, most human cancers have inactive Rb protein, either mutated Rb or the non-phosphorylated (inactivated form) of Rb protein

Adp Placement Papers

ADP Job Placement Paper Paper Type : Whole Testpaper Test Date : 24 October 2006 Test Location : P SRINIVAS REDDY I attended an interview for ADP The cut off % was 70% Around 150 to 250 members attended for the interview. from them they took Only 3 member The pattern of the interview is as follows 1. Written test 2. Two techinal interviews and 3.One HR WRITTEN TEST: It contained 4 sections SECTION A: verbal and Quantitative combined (40 questions 20 minutes) U should really manage the time such that u can answer both quantitative and verbal QUANTITATIVE :questions on -> profit and loss ( around 3 to 4 questions) -> boat and streams -> Alligations or Mixtures -> some on numbers †¦Ã¢â‚¬ ¦. quotient and remainder problems etc†¦Ã¢â‚¬ ¦.. Please practise RS agarwal for the quabtitativeVERBAL: It contains 10 analogies and 10 sentence completion questions If u hav pratised for GRE or GMAT, then it will be easy for. its better to Study barrons and big book SECTION B: te chnical section (20 questions 30 minutes) Around 15 to 18 questions are from C or may C++, and other related to data base concepts Practise â€Å"test ur c skills ,pointers in C† Most of the questions are related pointersSECTION C: (5 Questions , 20 minutes) In this section a big programme of around 2 to 3 pages was given and related to the Programe 5 questions are asked Please don't go through the entire programme just see the questions first and observe What part of the programme is really needed to answer that question SECTION D:(one passage , 10 minutes) Here they asked to write a passage on the topic given My topic was â€Å"My few favourite things† After the written test they short listed 30 studentsFIRST TECHNICAL INTERVIEW: Dont think technical means only technical questions, the two technical interviews were Like technical cum HR The questions asked in the first technical interview are 1. Tell me abt urself 2. Write a programme for binary seaching 3. What is a semaphore and where do we use them 4. What is meant by LRU(least recently used) 5. A puzzle 6. About ur family 7. About ur higher studies and plans for the future 8. Why adp 9. What is the diff between structures and unions 10. How we declare the variables in an union and so on†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. It went on for about 30 minutes SECOND TECHNICAL INTERVIEW: 1.Tell me about urself 2. About my family back ground 3. What is a linked list 4. What are the conditions that u put while traversing through a linked list 5. What is a computer, and what is internet. image that u are explaining this to A person who dint even see or knew what a computer really is and some other questions†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ It went on for about 20 minutes HR INTERVIEW: Hr interview was very cooooool. this round was just a formality and the questions Asked were 1. Tell me abt urself 2. Ur eamcet rank(its is competitive exam) and y so big rank 3. Ur family details 4. Y ADP? 5. Will u sign a bond of 3 yrs 6.Are u interested in further education and what are ur plans regarding that 7. What companies did u attend and y u lost in those and what r the companies U r planning to attend After all these interviews they hav short listed 7 students. they dint put further Round but depending on the performance they had selected 3 students I got selected ie. , i was one of those 3 students. This was my 8 company that i had attended and at last i got the job â€Å"SO GUYS NEVER GIVE UP TRY AND TRY, ONE DAY U WILL DEFINETLY SUCCEED † For any further information regarding the interview u can contact me at P SRINIVAS REDDY